Congratulations! Yunlong and Jianzhong's work about "Linking single-cell multiomics with GWAS to reveal key regulators of disease risk." was published by Nature Aging!
Congratulations! Jian, Yue, Yinghao, Shasha and Jianzhong's work about "Genome-wide association study reveals genetic architecture and evolution of human retinal pigmentation." was published by Science Advances!
Congratulations! Ming, Shasha, Jianzhong and Hui's work about "Protocol for modeling injury-induced regeneration in retinal organoids and isolating hNRSCs for subretinal transplantation in rd10 mice" was published by STAR Protocols!
Congratulations! Yunlong, Yinghao, Yijun, Wei and Jianzhong's work about "Integrating polygenic signals and single-cell multiomics identifies cell-type-specific regulomes critical for immune- and aging-related diseases" was published by Nature Aging!
Congratulations! Shasha, Hui and Jianzhong's work about "Chemical reprogramming of fibroblasts into retinal pigment epithelium cells for vision restoration" was published by Nature Communications!
Congratulations to Jianzhong's cooperative paper about "DNMT3A regulates murine megakaryocyte-biased hematopoietic stem cell fate decisions" was published on Blood Advances!
Congratulations! Dandan and Jianzhong' work about "NKX2-5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation" was published on Advanced Science!
Congratulations to Lijun and Jianzhong contributing a paper about "Cell-free DNA Fragmentomics Assay to Discriminate the Malignancy of Breast Nodules and Evaluate Treatment Response" on Genomics, Proteomics & Bioinformatics!
Congratulations! Jianzhong's work about "Transcriptomic profiling of blood platelets identifies a diagnostic signature for pancreatic cancer" was published by British Journal of Cancer!
Congratulations to Xingchen, Jiacheng, Shasha and Jian contributing a paper about "Whole-exome sequencing reveals sex difference in the genetic architecture of high myopia" on Journal of Medical Genetics!
Congratulations! Hui, Yunlong, Na and Jianzhong' work about "Identification and characterization of human retinal stem cells capable of retinal regeneration" was accepted by Science Translatitonal Medecine!
Congratulations! Jingjing, Yunlong and Jianzhong' work about "Integrating microbial GWAS and single cell transcriptomics reveals associations between host cell populations and the gut microbiome" was accepted by Nature Microbiology!
Congratulations to Yinghao and Jianzhong contributing a paper about "Whole-genome sequencing identifies novel loci for keratoconus and facilitates risk stratification in a Han Chinese population" on Eye and Vision!
Congratulations! Yinghao, Yuandong and Jianzhong' work about "Single Cell Inference of Cancer Drug Response Using Pathway-Based Transformer Network" was published on Small Methods!
Congratulations to Yunlong, Dingping and Jianzhong contributing a paper about "Systematic dissection of pleiotropic loci and critical regulons in excitatory neurons and microglia relevant to neuropsychiatric and ocular diseases" on Translational Psychiatry!
Congratulations! Jian, Ruowen and Jianzhong' work about "Exome-wide genetic risk score (ExGRS) to predict high myopia across multi-ancestry populations" was published on Communications Medicine!
Congratulations to Wei and Jianzhong contributing a paper about "RIP-AV: Joint Representative Instance Pre-training with Context Aware Network for Retinal Artery/Vein Segmentation" on Medical Image Computing and Computer Assisted Intervention – MICCAI 2024!
Congratulations! Yaru and Jianzhong' work about "Distinct discrepancy in breast cancer organoids recapitulation among molecular subtypes revealed by single-cell transcriptomes analysis" was published on Clinical and Translational Medicine!
Congratulations to Jingjing, Gongwei, Yunlong and Jianzhong contributing a paper about Mendelian randomization analysis reveals a causal effect of Streptococcus salivarius on diabetic retinopathy through regulating host fasting glucose on Journal of Cellular and Molecular Medicine!
Congratulations to Jian, Xiaoyu, Yue and Jianzhong contributing a paper about Exome-wide Association Study Identifies KDELR3 Mutations in Extreme Myopia on Nature Communications!
Congratulations to Hui, Shuaiyan, Shasha and Jianzhong contributing a review about Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration on Stem Cell Rev Rep!
Congratulations! Lijun, Chenghao and Jianzhong's collaboration work about Multimodal analysis of cell-free DNA methylomes for ultra-early detection of esophageal squamous cell carcinoma and precancerous lesions was accepted by Nature Communications!
Congratulations to Yang, Yunlong and Jianzhong contributing a paper about Endogenous mutant Huntingtin alters the corticogenesis via lowering Golgi recruiting ARF1 in cortical organoid on Molecular Psychiatry!
Congratulations to Zhenhui, Chenghao, Yue, Yinghao and Jianzhong contributing a paper about Histone 3 lysine 9 acetylation-specific reprogramming regulates esophageal squamous cell carcinoma progression and metastasis on Cancer Gene Therapy!
Congratulations to Jian, Kai and Jianzhong contributing a paper about Protocol for detecting rare and common genetic associations in whole-exome sequencing studies using MAGICpipeline on STAR Protocols!
Congratulations to Yinghao, Jiaying, Zhenhui and Jianzhong contributing a paper about DeepGraFT: A novel semantic segmentation auxiliary ROI-based deep learning framework for effective fundus tessellation classification on Computers in Biology and Medicine!
Congratulations to Jianzhong's collaborating paper about scDMV: A Zero-one Inflated Beta Mixture Model for DNA Methylation Variability with scBS-Seq Data was published on Bioinformatics!
Congratulations to Xiangyi, Jian, Jianzhong contributing a paper about Whole-Exome Sequencing Among School-Aged Children With High Myopia on JAMA Netw Open!
Congratulations to Yunlong, Yijun, Dingping, Wei and Jianzhong contributing a paper about Integration of human organoids single-cell transcriptomic profiles and human genetics repurposes critical cell type-specific drug targets for severe COVID-19 on Cell Proliferation!
Congratulations! Qi and Jianzhong's collaboration work about Network characterization linc1393 in the maintenance of pluripotency provides the principles for lncRNA targets prediction was published on iScience!
Congratulations to Yaru and Yonglong's co-first work about ESCC neoadjuvant anti-PD1 blockade was accepted by Cancer Cell!
Congratulations to Yunlong, Chunyu, Yijun and Jianzhong contributing a paper about Polygenic regression uncovers trait-relevant cellular contexts through pathway activation transformation of single-cell RNA sequencing data on Cell Genomics!
Congratulations to Zhenhui, Chenghao and Jianzhong contributing a review about Liquid biopsies for cancer: From bench to clinic on MedComm!
Congratulations! Meng, Siqi and Jianzhong contributed a paper about The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma on Nature Communications.
Congratulations! Shilai, Yinghao, Jianzhong contributed a paper about Association of mitochondrial DNA variation with high myopia in a Han Chinese population on Molecular Genetics and Genomics.
Congratulations! Jianzhong, Jian, Shilai contributed a paper about Sequencing of 19,219 exomes identifies a low-frequency variant in FKBP5 promoter predisposing to high myopia in a Han Chinese population on Cell Reports.
Xinyu, Lijun and Jianzhong contributed an article about Partial erosion on under-methylated regions and chromatin reprogramming contribute to oncogene activation in IDH mutant gliomas on Epigenetics & Chromatin. Congratulations!
Congratulations! Jianzhong's collaboration paper with Prof. Li about scRNA-seq reveals new subtypes of lens superficial tissue in humans was published on Cell Proliferation.
Congratulations! Xinrui and Zhengbo's review about the roles of non-coding RNAs in eye development and diseases was accepted on WIREs RNA.
Congratulations! Dandan and Xinyu's collaboration paper with Prof. Zhang about Mutant NPM1 hijacks transcriptional hub to maintain pathogenic gene programs in acute myeloid leukemia was accepted on Cancer Discovery.
Zhengbo, Yukuan, Zicheng, Congcong, Fangjie, Ji and Fukun graduated! Congratulations and best wishes!
Congratulations to Zhengbo, Jian, and Fukun, their paper about genetic relationships and pleiotropic mechanisms of five ocular diseases was accepted on eBioMedicine.
Congratulations! Yukuan and Hengqiang's collaboration paper with Prof. Wu about Identifying Hereditary Breast Cancer through Deep Learning was accepted on Genome Medicine！
Congratulations! Xinyu's collaboration paper with Prof. Lin about DNA methylation diagnostic and prognostic markers for esophageal squamous-cell carcinoma was accepted on Signal Transduction and Targeted Therapy.
Yunlong, Fei, Chunyu, Jingjing and Yukuan contributed a paper about integrating scRNA-seq with GWAS to discover genetics-influenced CD16+ monocytes and memory CD8+T cells involved in severe COVID-19 on Genome Medicine. Congratulations!
Merry Christmas and Happy New Year 2022!
Meng, Ping, Congcong, Jianzhong and Jie contributed a paper about Cell-free DNA 5-hydroxymethylcytosine of lncRNA as biomark for cancer on Clinical Epigenetics. Congratulations!
Congratulations. Chunyu and Jianzhong's collaboration paper about genetic source tracking of human urinary exosomes was accepted on PNAS.
Congratulations to Wei and Jianzhong for paper about non-classically secreted proteins in Gram-positive bacteria accepted by Nucleic Acids Research.
Congratulations! Yunlong, Jian and Jianzhong contributed a paper about whole city-million scale children and adolescents myopia survey (CAMS) in Wenzhou on Eye and Vision.
Congratulations! Jian, Qi, Dandan and Jianzhong's work about loss of H3K27me3 in ESCC activate transcription was accepted on npj Genomic Medicine.
Congratulations to Jianzhong for collaborative publication about de novo protein structure prediction in Bioinformatics.
Congratulations! Dandan's collaboration paper with Prof. Qiao about ESCC oncogenic enhancers was accepted in Nature Communications.
Jian, Fukun, Dandan and Jiangzhong contributed EyeDiseases database on NAR Genomics and Bioinformatics. Cheers!
Dandan, Siqi, Qi, Yaru and Ping successfully defended their MS theses. Congratulations!
Yunlong, Yukuan and Jianzhong's paper about genomic susceptibility locus of COVID-19 was published on Human Molecular Genetics. Congratulations!
Congratulations! Yunlong, jian, Yaru and Jianzhong's paper titled "COVID-19 quarantine reveals behavioral changes effect on myopia progression" was accepted on Ophthalmology.
Congratulations to Jian on his new baby girl. Cheers!
Hengqiang, Yukuan and Jianzhong contributed an article in Molecular Cancer. Congratulations!
Happy spring festival! Bless for 2021!
Congratulations to Yuanjian and Jianzhong for contributing a collaboration paper on The American Journal of Human Genetics. Cheers!
Congratulations! Jianzhong's collaboration paper with Li Lab is online at Nature Communications.
Yunlong had a baby girl. Congratulations!
Congratulations! Ping, Siqi and Dandan's work about DNA methylation signature in uveal melanoma was accepted in Briefings in Bioinformatics.
Congratulations! Siqi’s collaboration paper about an EV-derived GI-associated miRNA signature in breast cancer with Chen Lab and Wu Lab was accepted in Journal of Nanobiotechnology.
Merry Christmas & Happy New Year!
Congratulations! Yan, Fulong and Yaru's collaboration paper about single cell RNA-seq reveals cancerous origin with Jin Lab was accepted in PNAS.
Congratulations! Jianzhong Collaboration's paper about Discovery of Oncogenes and Tumor Suppressor Genes was published in Science Advance.
Su Lab had a wonderful day in Dongtou district.
Congratulations！ Yaru and Yunlong's work for pathway activity transformation of single-cell RNA-seq data was accepted in Computational and Structural Biotechnology Journal.
Congratulations! Jian Yuan and Dan Dan's work about cricial mitochondrial genes in cornea affected by COVID-19 was accepted in IOVS.
Congratulations! Jianzhong's collaboration paper with Li Lab was accepted in Nature Communications.
Congratulations! Yan and Yaru's paper of single-cell pathways annotation tool was accepted in Bioinformatics.
Congratulations! Xinyu's collaboration paper with Zhang Lab was published in Blood.
Congratulations! Yan, Zhengbo and Fangjie's ncRNAomics knowledgebase paper was accepted in Front Cell Dev Biol.
Congratulations! Jie, Zicheng and Siqi's tumor immune infiltration-associated lncRNAs in NSCLC paper was published in Journal for ImmunoTherapy of Cancer.
Congratulations! Long, Kai and Quan's Cell-free epigenome atlas in human diseases paper was published in Nucleic Acids Research
Happy New Year 2020！
Congratulations! Jian's molecular signatures in devastating endophthalmitis paper was accepted in mSystems
Congratulations! Yan and Long's circRNA in Alzheimer's disease paper was accepted in Frontiers in Bioengineering and Biotechnology
The lab welcomes new graduates: Zicheng Zhang, Ji Zhang, Yukuan Huang, Congcong Yan and Fukun Cheng
Celebrating the Success of International Forum of Genetics and Epigenetics in Precision Medicine, IFGE2019, and the Unveiling of the Biomedical Big Data Institute.
Merry Christmas！
Congratulations! Dr Su's grant application of outstanding youth has been funded by Zhejiang natural fund committee.
Congratulations! Dr. Su's grant application has been funded by NSFC.
Congratulations! Jianzhong's Pan-Cancer DNA Hypermethylation and homeobox oncogenes paper was published in Genome Biology
The lab welcomes new graduates: Dandan Fan, Siqi Bao, Qi Jiang, Yaru Zhang and Ping Hou
Our team at the 2018 Forum for Genetics and Epigenetics of Skeletal Associated Disorders meeting, Beijing, China
Professor Su was invited to the The International Consortium for Spinal Genetics, Development and Disease Conference